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PHARMACOLOGYAbsorption and Metabolism:
Carotenoids are absorbed like fats and transported via the lymphatic system into the liver. Absorption is dependent on the diet. Studies have demonstrated that higher fat diets increase lycopeneabsorption, while cholesterol-lowering drugs reduce its absorption. Also, lycopene from processed tomato products is more readily absorbed than that from raw tomatoes.
Pharmacokinetics After ingestion, lycopene is incorporated into lipid micelles in the small intestine. These micelles are formed from dietary fats and bile acids, and help to solubilize the hydrophobic lycopene and allow it to permeate the intestinal mucosal cells by a passive transport mechanism. Little is known about the liver metabolism of lycopene, but like other carotenoids, lycopene is incorporated into chylomicrons and released into the lymphatic system. In blood plasma, lycopene is eventually distributed into the very low and low density lipoprotein fractions.]Lycopene is mainly distributed to fatty tissues and organs such as the adrenal glands, liver, prostate and testes.
Role in photosynthesis Lycopene is a key intermediate in the biosynthesis of many carotenoids .Carotenoids like lycopene are important pigments found in photosynthetic pigment-protein complexes in plants, photosynthetic bacteria, fungi, and algae. They are responsible for the bright colors of fruits and vegetables, perform various functions in photosynthesis, and protect photosynthetic organisms from excessive light damage. Lycopene is a key intermediate in the biosynthesis of many important carotenoids, such as beta-carotene, and xanthophylls.
Antioxidant Properties and Potential Health Benefits Lycopene may be the most powerful carotenoid quencher of singlet oxygen, being 100 times more efficient in test tube studies of singlet-oxygen quenching action than vitamin E, which in turn has 125 times the quenching action of glutathione (water soluble)]. Singlet oxygen produced during exposure to ultraviolet light is a primary cause of skin aging. In addition, a lycopene metabolite apo-10'-lycopenal, or ALA, may have an important role in the metabolism of hepatic lipids, and may prevent build up. The build up of lipids in the liver can result in non-alcoholic fatty liver disease, or NAFLD. NAFLD can progress to more serious conditions, such as, fibrosis, cirrhosis, and hepatocellular carcinoma. If you are currently using any of the medications listed above, tell your doctor or pharmacist before starting this multivitamin. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: hydantoins (e.g., phenytoin), methotrexate, pyrimethamine, other vitamin/mineral/nutritionalsupplements Interactions This product should not be used with the following medications because a very serious interaction may occur:
200ml (With Carton)