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VASTIF -SF ( TERBUTALINE SULPHATE 1.25MG , BROMHEXINE HYDROCHLORIDE IP 2MG , GUAIPHENESIN IP 50MG , MENTHOL IP 0.5MG )  PACKING- 100ML (100)

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This medication is a combination of Calcium and Calcitriol in which calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Calcium is necessary for many normal functions of our body, especially bone formation and maintenance. Calcium also binds to other minerals (such as phosphate) and aid in their removal from the body. Calcitriol helps in the control of some conditions that arise because of fluctuating levels of the parathyroid hormone in the body.

Indications

• To prevent or treat low blood calcium levels.
• Osteoporosis
• Osteomalacia
• Rickets
• Hyperparathyroidism

Dosage

Oral:
Tablet may be taken with or without food.
Disclaimer: To be taken only after consulting with the doctor.

For Professionals
Pharmacodynamics Properties of Calcium Citrate

Increases plasma calcium levels leading to a decrease in calcium flux and increase in calcium deposition into bone.

MECHANISM OF ACTION

Calcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH)???[3]. Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption.

Pharmacokinetics Properties of Calcium Citrate

Absorption from the GI tract requires Vitamin D. Available elemental calcium depends on the salt form used, dose administered and the presence of an acid environment in the stomach. Elimination is primarily in the feces as unabsorbed calcium and the kidneys eliminate 20%.

Pharmacodynamics Properties of Calcitriol

Calcitriol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the GIT and its utilization in the body.

MECHANISM OF ACTION

Calcitriol is a 1, 25-dihydroxycholecalciferol or a Vitamin D analogue. It increases the absorption of Calcium from intestine by forming a calcium binding protein. It reverses the signs of rickets and osteomalacia.

Pharmacokinetics
Properties of Calcium Citrate

Absorption: It is readily absorbed after oral administration.
Distribution: It is widely distributed in protein bound form.
Metabolism: It undergoes metabolism in the liver and kidney.
Excretion: It is excreted mainly in the faces.

Side Effects
Very rare but common side effects are:

•  Nausea or vomiting
•  Decreased appetite;
•  Constipation;
•  Dry mouth or increased thirst; or
•  Increased urination

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We are actively engaged in marketing of broad range of Iron & Folic Acid Syrup.

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Our organization is widely trusted in offering Zemoxtif 500 mg Capsule.

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We are actively engaged in marketing of broad range of Atmofurox 250 mg and 500 mg Tablet.

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We offer our clients the qualitative range of Artemether Injection. Our provided injection is used as treatment of fevers. This injection is widely acknowledged by our client for its purity and precise composition. 

Features:

• Purity
• Effectiveness
• Accurate composition

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Our organization is widely trusted in offering Adinotif 200 mg Tablets. 

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ATMOCAL-K2-MAX CAPS                                                Calcium Citrrate Malate, Calcitriol, Vitamin K2-7, Omega-3 Marine Triglycerides (Fish Oil), Folic Acid & Boron Softgel Capsules                                                                                PACKING- 10X1X10 (BLISTER)                                                 

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ALIPEPTIN-S 200ML SYP                                                        TRICHOLINE CITRATE 0.55, Sorbitol Solution 70% Q.S (WITH CARTON)                                                                                PACKING-200ML (60) 

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We are actively engaged in marketing of broad range of Paracetamol and Phenylepherine Suspension.

Composition Each 5ml Contains:

• Paracetamol IP 125 mg
• Phenylepherine HCL IP 2.5 mg
• Chlorpheniramine Maleate IP 2 mg Packing60ml (With Carton)
• PHARMACOLOGY
• Paracetamol is an effective analgesic-antipyretic (relieves mild to moderate pain) and a weak anti-inflammatory agent.

Absorption:

• It is readily absorbed from the g.i. tract with peak plasma concentrations occurring about 10 to 60 min. after oral administration.

Distribution:

• It is distributed into most body tissues.

Elimination:

• Approximately 80% of acetaminophen is excreted in the urine after conjugation and about 3% is excreted unchanged.

Half Life:

• 1 to 4 hours.

• Chlorpheniramine Maleate is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. Chlorpheniramine binds to the histamine H1 receptor. This block the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Absorption:

• Well absorbed in the gastrointestinal tract.

Protein Binding:

• 72%.

Metabolism:

• Primarily hepatic via Cytochrome P450 (CYP450) enzymes.

Half Life:

• 21-27 hours.
• Phenylephrine Hydrochloride is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells.

Absorption:

• Completely absorbed after oral administration. Peak serum concentrations are achieved approximately 0.75-2 hours following oral administration.

Protein Binding:

• 95% binding-plasma proteins.

Metabolism:

• Undergoes extensive first-pass metabolism in the intestinal wall and extensive metabolism in the liver.

Route of Elimination:

• Phenylephrine and its metabolites are mainly excreted in urine.

Half Life:

• 2.1 to 3.4 hours.

INTERACTIONS The following class of drugs if co-administered with the medication may cause severe drug interactions:

• Anti-depressants, sympathomimetic agents(epinephrine), Anesthetics(halothane), adrenergic-blocking agent (e.g., Phenothiazine drugs) and any other drug containing acetaminophen.

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Anti-Diabetic Agents

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Our organization is widely trusted in offering Atmotran MF Tablet.

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We are offering Artemether Tablets IP 80mg, Lumefantrine 480 mg.

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Atmocal comprises of Alfacalcidol, Calcium carbonate and Betacarotene which is used for calcium metabolis, improvement of muscle strength, and requiring a prompt increase in blood plasma calcium concentrations. Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Calcium carbonate is essential for maintaining the functional integrity of nervous, muscular, and skeletal system. Beta carotene promotes growth, the immune system.

Indications?

• Osteoporosis 
• Bone spur and Increase bone mineral density
• Enhances calcium absorption
• Growth and repair of body tissues
• Helps in formation of healthy bones & teeth, muscles, nervous system & heart.

Warning & Precautions
Consult your doctor or pharmacist before taking this combination if:

• You are allergic to any of this ingredients
• You are hypersensitive
• You are pregnant or planning to be become pregnant
• You have liver disease.

Contraindications

• Second and third trimesters of pregnancy.
• Biliary obstructive disorders.
• Severe hepatic impairment.

Side Effects

• Nausea
• Upset stomach
• Dry mouth
• Diarrhoea
• Headache

Oral:
Disclaimer: To be taken only after consulting with the doctor.

Pharmacodynamics:

Pharmacodynamics Properties of Calcium Carbonate

Calcium Carbonate is essential for maintaining the functional integrity of nervous, muscular, coagulation of blood and skeletal system. It controls excitability of nerves and muscles and regulates permeability of cell membrane. It also regulates cell adhesion and maintains integrity of cell membrane. Calcium acts as intracellular messenger for hormones, autacoids, and transmitters. Plasma concentration of calcium is kept in normal range by three endocrine factors i.e,  Parathyroid hormone, Calcitonin, Vitamin D which control metabolism of calcium.

Pharmacodynamics Properties of Alfacalcidol

Alfacalcido is a Nutritional supplement,Vitamin D derivative, Antihypoparathyroid, Antihypocalcemic. It is Vitamin D-hormone analog which is due to increased concentrations of 1,25-dihydroxycholecalciferol in the circulation, which leads to increased intestinal absorption of calcium and phosphate. This promotes bone mineralisation, reduces parathormone concentrations and inhibits bone resorption. 

Pharmacodynamic Properties of Beta Carotene

Beta carotene is a natural precursor to Vitamin A.It helps in maintains proper bone growthand maintenance of spermatogenesis.Oral administration of beta-carotene increases the serum concentration of beta-carotene by 60% but it does not change the concentration found in the heart, liver or kidneys. It ameliorates oxidative stress, enhances antioxidant activity and decreases apoptosis. It is thought to have detoxifying properties, as well as to help increase resistance to inflammation and infection and increase immune response and enhance RNA production

Pharmacokinetics:
Pharmacokinetics Properties of Calcium Carbonate

Absorption: Actively absorbed from gastrointestinal tract in an ionized form; and vitamin D in its active form is required for calcium absorption.

Distribution: Distributed mainly in to skeletal tissue (99%) and 1% is distributed equally between the intracellular and extra cellular fluid. CSF levels are about half of the serum calcium levels Metabolism: Not significantly metabolized in the body.
Excretion: Excreted mainly through faeces and a small amount is excreted through urine.

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Our organization is widely trusted in offering Atmonil 50 mg Tablet.

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Our organization is widely trusted in offering Atmozone-s Injection.

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ATMOFERON   (IRON ORAL SPRAY)                COMPOSITION - ENERGY 0.52 KCAL, CARBOHYDRATE 0.13G, PROTEIN 0.00 G FAT.00 G, IRON (AS FERRIC AMMONIUM CITRATE) 4.2MG , ( Delicious APPLE FLAVOUR).                     
PACKING- 192/25 ML *128 (WITH CARTON)  MRP- 220/-