Alvizia Healthcare Private Limited
Alvizia Healthcare Private Limited
Sector 38, Chandigarh
GST No. 04AANCA7058A1ZX
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NUTRACEUTICAL


Manufacturer of a wide range of products which include atmocal calcium carbonate vitamin d3 tablets, vgdot - m 500 tabs and atmocal-ct calcium citrate calcium calcitrol tablets.

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Approx. Rs 58 / Pack Get Latest Price

Product Details:
BrandAtmocal
CompositionCalcium Carbonate IP1250 mg Vitamin D3 IP250 IU
Packaging Size10 x 15
FormTablet
Packaging TypeBox
Medicine TypeAllopathic
Grade StandardMedicine
ManufacturerAlvizia Healthcare

This combination medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone). Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Having the right amounts of vitamin D, calcium, and phosphorus is important for building and keeping strong bones

Indications
  • Osteoporosis
  • Osteomalacia/Rickets
  • Hypoparathyroidism
  • Pregnant, nursing or postmenopausal women
  • Normal functioning of nerves, muscles, cells, bones
Warnings

Always get advice from a healthcare professional before taking this medicine if:

  • you are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • this medicine is for a child or an adolescent
  • you have a history of kidney stones or calcium deposits in your kidneys
  • you have kidney problems
  • you have high levels of calcium in your blood or urine, or this has been caused by having certain conditions such as hyperparathyroidism, cancer or bone tumours
  • your osteoporosis is caused by being immobile
  • you have vitamin D poisoning
  • you have sarcoidosis
  • you are taking calcium and vitamin D supplements
  • you have a history of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency
Pregnancy and breast-feeding: This medicine is not known to cause any problems during pregnancy or while breast-feeding. However, as with all medicines, you should seek medical advice from your doctor before taking this medicine if you are pregnant or are breast-feeding.
Dosage

Oral:
Tablet may be taken with or without food.
Disclaimer:To be taken only after consulting with the doctor.

Absorption:
Calcium Carbonate: About 15-25% gets absorbed in the GI tract and converted to calcium chloride by gastric acid. Some of the calcium is absorbed in the intestines. Calcium is absorbed in soluble, ionized form; solubility of calcium is increased in an acidic environment.
Vitamin D: Well-absorbed in the GI tract in the presence of bile.

Distribution:
Calcium Carbonate: Crosses placenta, enters breast milk.
Vitamin D: Bound to a specific α-globulin and can be stored in adipose & muscle tissue for long periods of time. Slowly released from storage sites & skin where it is formed in the presence of sunlight or uv light. It may distribute into breast milk.

Metabolism:
Vitamin D: Hydroxylated in the liver by the enzyme vitamin D 25-hydroxylase to form 25-hydroxycholecalciferol (calcifediol). Further hydroxylated in the kidneys by the enzyme vitamin D1-hydroxylase to form the active metabolites 1,25-dihydroxycholecalciferol (calcitriol). Then metabolism also occurs in the kidneys, including the formation of the 1,24,25-trihydroxy derivatives.

Excretion:
Calcium Carbonate: Mainly in the faeces as unabsorbed calcium; urine (20%).
Vitamin D3: Mainly in the bile & faeces with only small amounts appearing in urine.

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Approx. Rs 125 / Strip Get Latest Price

Product Details:
Minimum Order Quantity5000 Strip
Prescription/Non prescriptionPrescription
Shelf life2 years
ManufacturerAlvizia healthcare
CompositionVildagliptin 50 mg & Metformin Hcl 500
FormTablet
Country of OriginMade in India
Packaging Size10X10 (ALU-ALU)
BrandVGDOT - M 500 TABS

COMPOSITION - Vildagliptin 50 mg & Metformin Hcl 500

Additional Information:
  • Packaging Details: 10X10 (ALU-ALU

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Approx. Rs 65 / Pack Get Latest Price

Product Details:
BrandAtmocal-CT
ManufacturerAlvizia Healthcare
Packaging size10 x 3 x 10
CompositionCalcium Citrate USP 1200 mg Eq To Elemental Calcium 252 mg,Calcitriol IP 0.25 mcg
Packaging TypeBox
FormTablet
Medicine TypeAllopathic
Grade StandardMedicine

This medication is a combination of Calcium and Calcitriol in which calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Calcium is necessary for many normal functions of our body, especially bone formation and maintenance. Calcium also binds to other minerals (such as phosphate) and aid in their removal from the body. Calcitriol helps in the control of some conditions that arise because of fluctuating levels of the parathyroid hormone in the body.

Indications
  • To prevent or treat low blood calcium levels.
  • Osteoporosis
  • Osteomalacia
  • Rickets
  • Hyperparathyroidism


Dosage

Oral:
Tablet may be taken with or without food.
Disclaimer: To be taken only after consulting with the doctor.

For Professionals
Pharmacodynamics Properties of Calcium Citrate

Increases plasma calcium levels leading to a decrease in calcium flux and increase in calcium deposition into bone.

MECHANISM OF ACTION

Calcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH)???[3]. Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption.

Pharmacokinetics Properties of Calcium Citrate

Absorption from the GI tract requires Vitamin D. Available elemental calcium depends on the salt form used, dose administered and the presence of an acid environment in the stomach. Elimination is primarily in the feces as unabsorbed calcium and the kidneys eliminate 20%.

Pharmacodynamics Properties of Calcitriol

Calcitriol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the GIT and its utilization in the body.

MECHANISM OF ACTION

Calcitriol is a 1, 25-dihydroxycholecalciferol or a Vitamin D analogue. It increases the absorption of Calcium from intestine by forming a calcium binding protein. It reverses the signs of rickets and osteomalacia.

Pharmacokinetics
Properties of Calcium Citrate

Absorption: It is readily absorbed after oral administration.
Distribution: It is widely distributed in protein bound form.
Metabolism: It undergoes metabolism in the liver and kidney.
Excretion: It is excreted mainly in the faces.


Side Effects
Very rare but common side effects are:
  •  Nausea or vomiting
  •  Decreased appetite;
  •  Constipation;
  •  Dry mouth or increased thirst; or
  •  Increased urination

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Anjum Aggarwal  (Managing Director)
Alvizia Healthcare Private Limited
SCO 165, Ground Floor, Sector 38-C
Chandigarh - 160036 , India
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